4,8/5 com base em
44.878 avaliações
Annita Oral Suspension 45ml
What is it for?
Annita is indicated for the treatment of the following infections:
- Viral gastroenteritis caused by rotavirus and norovirus;
- Helminthiasis caused by nematodes, cestodes, and trematodes, such as Enterobius vermicularis , Ascaris lumbricoides , Strongyloides stercolaris , Ancylostoma duodenale , Necator americanus , Trichuris trichiura, Taenia sp and Hymenolepis nana ;
- Amebiasis, for the treatment of diarrhea due to acute intestinal amebiasis or amebic dysentery caused by the complex. Entamoeba histolytica/dispar ;
- Giardiasis, for the treatment of diarrhea caused by Giardia lamblia or Giardia intestinalis ;
- Cryptosporidiosis, for the treatment of diarrhea caused by Cryptosporidium parvum ;
- Blastocystosis, balantidiasis and isosporiasis, caused, respectively, by Blastocystis hominis, Balantidium coli and Isospora belli.
How does Annita Suspension work?
Annita acts against protozoa by inhibiting an enzyme essential to the parasite's life. The same seems to occur with worms, although other mechanisms, not yet fully understood, may be involved.
The action on viruses occurs through the inhibition of viral structure synthesis, blocking the virus's ability to multiply.
The average time the medication takes to take effect is estimated to be between two and four hours after administration.
How to use
Annita should be taken with food, which ensures high absorption of the medication.
Prepare the suspension immediately before using it for the first time, as instructed below:
- Shake the closed bottle vigorously to loosen the powder from the bottom.
- Add boiled or filtered water up to the mark indicated on the label.
- Place the syringe adapter on the bottle.
- Cap the bottle and shake vigorously to obtain a homogeneous suspension. If necessary, add more filtered water up to the mark indicated on the label and shake to homogenize.
- The volume of the suspension should be measured using the syringe. Fit the syringe into the opening of the inner cap of the bottle, turn it upside down, and pull the plunger until the volume prescribed by your doctor is reached.
- The suspension can be administered directly from the syringe into the mouth or, if desired, it can be transferred to a spoon before administration.
Any unused portion of the oral suspension, after the maximum storage period of seven days, should be discarded.
Attention: Dosing syringe for exclusive use with Annita suspension. After use, wash it under running water and store it for the next dose.
Dosage of Annita Suspension
| Indication | Dosage | Duration |
| Viral gastroenteritis caused by rotavirus and norovirus. | 0.375 mL (7.5 mg) per kg, twice a day (every 12 hours) | 3 consecutive days |
| Helminthiasis, amebiasis, giardiasis, isosporiasis, balantidiasis, blastocystosis | 0.375 mL (7.5 mg) per kg, twice a day (every 12 hours) | 3 consecutive days |
| Cryptosporidiosis in non-immunocompromised patients | 0.375 mL (7.5 mg) per kg, twice a day (every 12 hours) | 3 consecutive days |
| Cryptosporidiosis in immunocompromised patients, if the CD4 count is greater than 50 cells/ mm3 | 0.375 mL (7.5 mg) per kg, twice a day (every 12 hours) | 14 consecutive days |
| Cryptosporidiosis in immunocompromised patients, if the CD4 count is less than 50 cells/ mm3 | 0.375 mL (7.5 mg) per kg, twice a day (every 12 hours) | Medication should be continued for at least eight weeks or until symptoms resolve and oocysts become negative. |
What should I do if I forget to use Annita Suspension?
If you forget to take a dose, take it immediately and continue your regular dosing schedule. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule by taking the next dose at the usual time. Do not double the dose to make up for a missed dose.
Composition
Presentation
Powder for oral suspension – nitazoxanide 20 mg/mL – package containing a bottle with 45 mL or 100 mL after reconstitution.
Composition
Each mL of the reconstituted suspension contains:
20mg of nitazoxanide.
Excipients: Sodium benzoate, sucrose, xanthan gum, microcrystalline cellulose, sodium carboxymethylcellulose, citric acid, sodium citrate dihydrate, red dye no. 33 and strawberry flavoring.
Precautions
The following hygiene measures are recommended to combat parasitic infections:
- Wash fruits and vegetables thoroughly;
- Wash household utensils thoroughly;
- Keep food and water containers covered;
- Keep your hands clean and your nails trimmed, avoid putting them in your mouth, and wash them before meals and after using the toilet.
- Use treated, filtered, or boiled water, and do not drink water from unsuitable containers.
- Maintain a suitable place for the disposal of human or animal feces (septic tanks and latrines), defecate in an appropriate place (toilet) and keep sanitary facilities clean;
- Do not use human feces as fertilizer;
- Do not eat raw or undercooked pork and/or beef;
- Do not buy meat of dubious origin;
- Do not walk barefoot in potentially infected areas.
Lactation (breastfeeding)
Annita should only be used by breastfeeding women if the doctor determines that the benefits justify the potential risk to the infant (child being breastfed).
Pregnancy
Annita should only be used during pregnancy if the doctor determines that the benefits justify the potential risk to the fetus.
Adverse reactions
Common side effects (occurring in 1% to 10% of patients using this medication):
Abdominal pain of the colic type, diarrhea, nausea, vomiting, and headache.
Uncommon reactions (occurring in 0.1% to 1% of patients using this medication):
Allergic reaction, increased blood levels of glutamic pyruvic transaminase (a liver enzyme), anemia, increased appetite, increased blood creatinine, hyperhidrosis (excessive sweating), dizziness, light yellowing of the eyes, fever, flatulence (gas), hypertension (high blood pressure), pruritus (itching), rhinitis, enlarged salivary glands, tachycardia (rapid heartbeat), yellowish or greenish-yellow discoloration of urine or semen.
Annita may cause a change in the color of physiological fluids (e.g., urine and semen) to greenish-yellow, without any clinical significance. This is due to the coloring of some of the components of the formula. If the altered color persists after discontinuing use of the medication, consult your doctor.
Overdose
In case of overdose, medical advice should be sought. Symptoms and signs may be limited to abdominal pain, nausea, vomiting, and diarrhea. Gastric lavage may be effective if performed soon after ingestion of the medication. Patients should be carefully monitored and receive symptomatic support.
Food interaction
Ingesting nitazoxanide (the active substance) with food increases the area under the plasma concentration-time curve (AUC) and also the Cmax .
Contraindications
You should not use Annita if you have any of the following conditions:
- Diabetes, liver disease, or kidney disease;
- Hypersensitivity (allergy) to any of the components of the formula.